Spina bifida: Spina bifida occurs when the spinal bones fail to close properly during early formation. It occurs in about 1 in 1, 000 births and is the most common of the physically disabling congenital abnormalities. A parent who has one child with spina bifida has a greater chance (1 out of a 100) of having another. This increased frequency appears to be due to combined effect of heredity and the environment.
Answered 8/10/2012
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NO.: Increased msafp (maternal serum Alpha fetoprotein) is a marker of open fetal defects (spina bifida aperta, encephalocele, gastroschisis, omphalocele, amniotic band sequence, cleft lip/palate) and placental anomalies (accreta, chorioangiomas). The most common reason for a positive screen without prior ultrasound is wrong due date! relax, talk to your genetic counselor and get a detailed ultrasound!
Answered 4/7/2018
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