Anyone know anything about scleroderma?

It is immunmediated : People with scleroderma have thickening of their skin and with this you blood vessel thickening that can lead to hypertension, kidney, lung and heart problems. It is felt to be immune mediated people can have autoimmune phenomen such antibodies to the nucleus it is felt to be an autoimmune disease.

Autoimmune disease : Scleroderma literally means, "hard skin" which is a prominent feature. It is an autoimmune disease that results from cells making excess collagen which hardens and tightens the skin and blood vessels and sometimes internal organs. The severity can vary greatly from person to person. Fortunately, it is a rare disease. A rheumatologist is the best doctor to evaluate and treat this disease.