A member asked:

What is a class 3 allergy?

3 doctors weighed in across 3 answers
Dr. Stevan Cordas answered

Specializes in Internal Medicine

Class 3 allergy: This is confusing. First, in doing prick tests for allergies on the skin we grade it from one to four. Secondly some use such a term for anaphylaxis wich is not neccessarily ige mediated http://www.Ajronline.Org/content/190/3/666.Full then there are gell-combs reactions which are type i to iv is that what you mean?

Answered 8/3/2012

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Dr. David Shulan answered

Specializes in Allergy and Immunology

Type 3: I assume you mean a type 3 immune reaction which is caused by immunoglobulins (antibodies) binding specific materials (antigens) forming a complex that can activate materials in the blood to cause inflammation. This can occur in serum sickness, lupus, hepatitis and many other conditions.

Answered 10/18/2016

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Moderate RAST result: Dr. Shulan is correct: type 3 immune reactions involve igg & antigen. "class 3 allergy" may also refer to rast, a blood test for detecting ige against antigen. For convenience labs define from 5 to 7 levels. Class 2 is often borderline & class 3 low positive. But positive is positive. There is little significant difference between class 3 & class 6. Photo: dr & dr ishizaka, discoverers of ige.

Answered 10/5/2016

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