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A 36-year-old member asked:

What is a class 3 allergy?

3 doctor answers3 doctors weighed in
Dr. Stevan Cordas
Internal Medicine 57 years experience
Class 3 allergy: This is confusing. First, in doing prick tests for allergies on the skin we grade it from one to four. Secondly some use such a term for anaphylaxis wich is not neccessarily ige mediated http://www.Ajronline.Org/content/190/3/666.Full then there are gell-combs reactions which are type i to iv is that what you mean?
Dr. David Shulan
Allergy and Immunology 41 years experience
Type 3: I assume you mean a type 3 immune reaction which is caused by immunoglobulins (antibodies) binding specific materials (antigens) forming a complex that can activate materials in the blood to cause inflammation. This can occur in serum sickness, lupus, hepatitis and many other conditions.
Dr. Steven Machtinger
Allergy and Immunology 44 years experience
Moderate RAST result: Dr. Shulan is correct: type 3 immune reactions involve igg & antigen. "class 3 allergy" may also refer to rast, a blood test for detecting ige against antigen. For convenience labs define from 5 to 7 levels. Class 2 is often borderline & class 3 low positive. But positive is positive. There is little significant difference between class 3 & class 6. Photo: dr & dr ishizaka, discoverers of ige.

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Last updated Oct 18, 2016

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