How does pml affect people with hiv?

Poor prognosis: Pml is an infection of the brain by the jc virus, that usually only occurs if the immune system is very compromised (full blown aids, on transplant meds or some other meds). It causes brain damage and is usually fatal within a year when it does occur in aids.

PML and HIV: Progressive multifocal leukoencephalopathy affects individuals with compromised immune system disorders. In patients with aids, efforts to improve the immune system may improve the course and outcome of pml.