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A 41-year-old member asked:

what does it mean if i have a simian crease on both hands?

3 doctor answers7 doctors weighed in
Dr. Joseph Woods
Pathology 28 years experience
Can mean nothing.: This is usually associated with syndromes like fetal alcohol syndrome, and the trisomies like down's syndrome, etc.. But it does not have to be associated with them or anything. To have it on both hands is rare: %5 population. It is apparently more common among asians and native americans than among other populations.
Dr. Jeffrey Wint
Hand Surgery 35 years experience
Simian crease: a single crease in the palm vs the multiple transverse creates many have may mean nothing at all . While rare about 1 in 30 of so called "normal" people have this. There is also a long list of syndromes and illnesses associated with a simian crease. But if you had one of those you'd know it , be born with it and you can't catch those things from others
Dr. Ecaterina Sartina
Pediatrics 35 years experience
May be nothing: If you have only this particular sign and no other signs and well otherwise, it means- nothing. If it comes with the constellation of some other specific signs and symptoms, pediatricians look for certain chromosomal disease, such as down's syndrome.

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A 30-year-old member asked:

What does it mean to have simian creases on both hands?

1 doctor answer1 doctor weighed in
Dr. Jeffrey Wint
Hand Surgery 35 years experience
Simian crease: Simian crease occurs in about 1 out of 30 normal people, but is also frequently associated with other conditions such as down syndrome, aarskog syndrome or fetal alcohol syndrome. F.
A 38-year-old member asked:

Is it rare to have a simian crease on both hands?

1 doctor answer2 doctors weighed in
Dr. Ecaterina Sartina
Pediatrics 35 years experience
It's rare: It might be ~ 0.5-1% in the population. It's minor deviation and doesn't mean anything if no other signs or symptoms present. It's commonly associated with Down syndrome or trisomy 21.
A 33-year-old member asked:

Please help! I have a simian crease on both hands. What does this mean?

1 doctor answer6 doctors weighed in
Dr. Tanya Russo
Pediatrics 25 years experience
Single palmar crease: Single palm creases are believed to develop around 12 weeks gestation. Any insult to the developing fetus can produce these creases and associated neurologic defects. They are commonly associated with Down's Syndrome, other genetic defects, neurologic disorders and possibly Fetal Alcohol Syndrome. They are present in a small percent of the population with no other significant issues.

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Last updated May 28, 2019

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