A member asked:

Is it possible for methylphenidate produce tolerance for amphetamines? or the other way around?

A doctor has provided 1 answer
Dr. Jay Park answered

No: Methylphenidate and amphetamine are two different, chemically unrelated stimulants. Of the 20-30% of nonresponders to one medication, about half will respond to the other stimulant.

Answered 10/14/2014

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