A 45-year-old female asked:
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do i have scleroderma 46 year old female positive. ana two times 1:40 and 1:160 negative nucleolar pattern negative subtests . no skin issues , eye irritation once in awhile. ana tests done 1 1/2 years ago . rheumatalogist finds nothing except ana and i

1 doctor answer
Dr. Jennifer Giltnane
13 years experience Pathology
Unlikely : The combination of your very low ANA titers and lack of symptoms make scleroderma unlikely. Patterns of ANA are not reproducible, and an ANA titer of <1:80 has been reported in up to 13% of healthy patients. Ana is a screening assay which should be followed by a more specific autoantibody tests. 95% of scleroderma patients will have an identifiable positive autoantibody. (uptodate.Com, 7/16/12).
Answered on Jun 10, 2014
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