A member asked:

Can nephrotic syndrome be caused by multiple myeloma?

7 doctors weighed in across 3 answers
Dr. Edward Gold answered

Specializes in Internal Medicine

Yes: Myeloma cells can produce abnormal immune proteins called "light chains" which can affect the kidney and result in renal failure and/or nephrotic syndrome.

Answered 12/22/2016

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Dr. Kevin Griffiths answered

Specializes in Nephrology and Dialysis

Yes: Although rare, multiple myeloma (mm) can cause nephrotic syndrome. Mm is more likely to cause renal impariment, mild protein spill from your kidneys, back pain and electrolyte disturbances in your bloodwork.

Answered 7/20/2012

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Dr. Keith Stockerl-Goldstein answered

Specializes in Hematology and Oncology

Yes: This can happen but usually myeloma causes a decrease in the kidney function. Some patients with myeloma can also have a protein deposited in the kidney (amyloidosis) that can lead to nephrotic syndrome.

Answered 12/22/2016

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