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A 40-year-old member asked:

Can nephrotic syndrome be caused by multiple myeloma?

3 doctor answers7 doctors weighed in
Dr. Edward Gold
Internal Medicine 46 years experience
Yes: Myeloma cells can produce abnormal immune proteins called "light chains" which can affect the kidney and result in renal failure and/or nephrotic syndrome.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Kevin Griffiths
Specializes in Nephrology and Dialysis
Yes: Although rare, multiple myeloma (mm) can cause nephrotic syndrome. Mm is more likely to cause renal impariment, mild protein spill from your kidneys, back pain and electrolyte disturbances in your bloodwork.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Keith Stockerl-Goldstein
Hematology and Oncology 32 years experience
Yes: This can happen but usually myeloma causes a decrease in the kidney function. Some patients with myeloma can also have a protein deposited in the kidney (amyloidosis) that can lead to nephrotic syndrome.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Dec 22, 2016
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