No u: No usually classic murmur is pansystolic (all the way through systole but stops with the second heart sound).
Answered 1/31/2015
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Holosystolic: Classically, a vsd results in increased blood flow from left to right ventricle due to pressure differences and results in a holosystolic murmur. Several situations where a diastolic murmur may be heard is 1) large vsd results in aortic cusp sucking into vsd and aortic regurg, 2) very large defect with so much flow to lungs and back to left side with diastolic rumble through mitral valve.
Answered 10/15/2012
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Two ways: A large vsd with increased pulmonary blood flow may cause a diastolic flow rumble caused by a large amount of flow coming back from the lungs across the mitral valve into the left ventricle. Perimembranous and supracristal vsds can cause aortic valve deformation, and subsequent development of a diastolic murmur of aortic valve insufficiency.
Answered 12/24/2014
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