What should i do if my wife has manic depression? is it possible to stay married?

Bipolar: Sure it is. As long as she has good support system, good therapist, and complies with prescribed medications if she is on meds., prognosis is favorable.

He has to want it: Your wife has to want therapy and medication, and all you can really do is encourage her to seek both and engage deeply and meaningfully in the therapeutic process. You simply cannot do it for her, much as you'd like to. You can either be her husband or her therapist. You cannot be both, and even though you want to see her get better, trying to be both simply will not work. Yes, it is possible.

Manic Depression: Manic Depression leads to a breakdown in logic. It is important your wife finds the correct combination of medications with her Psychiatrist. But medications alone are not sufficient because they do not teach coping mechanisms. Psychotherapy with a Clinical Psychologist can help her find ways to handle problems with her thinking and help her medications work better.