What's the best prevention for cardiovascular diseases?

Lifestyle modifying: Best is picking your parents carefully. Genetics plays a huge role, but lifestyle and habits can significantly mitigate risk. Weight control, prudent diet (heavy on plant based foods & minimal meat), exercise, no smoking, control of blood pressure and blood sugar. If still not at goal levels, judicious use of medications to evidence-based targets of therapy are your best bet. Talk to your doc.