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A 29-year-old member asked:

Does wilson's disease lead to leukemia?

2 doctor answers2 doctors weighed in
Dr. Weili Sun
Pediatric Hematology and Oncology 28 years experience
No: Wilson disease is the genetic disorder cause abnormal cooper metabolism. It usually cause liver and central nervous system abnormality. There is no evidence that wilson disease can cause leukemia or the incidence of leukemia is high in children with wilson disease.
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Dr. Ed Friedlander
Pathology 46 years experience
I doubt it: Wilson's is rare and when two youngsters with it came down with leukemia, there was talk about either the copper overload or the Penicillamine rx possibly being a cause. Wilson's is very serious and i wouldn't worry about an old claim of a link that was first made in 1982 without any real further validation.
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Similar questions

A 47-year-old member asked:

How does wilson's disease eventually lead to leukemia?

1 doctor answer1 doctor weighed in
Dr. Christian Schultheis
Hematology and Oncology 26 years experience
Rare: There is an increases risk for hepatocellular (liver) carcinoma. I am not aware of an increased leukemia risk. Copper deficiency can cause a myriad of hematologic manifestations. There have been case reports of patients with wilson's disease developing leukemia, but the thought was that they were unrelated. Hope this helps.
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Last updated Aug 9, 2014
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