Can there be changes in rheumatoid factor?

YES: Rheumatoid factors can change sometimes day to day and also how the test is done. It also may change with the level of disease activity.

Depends!: If a patient has RA, RF will go down with traditional DMARD Rx: sulphasalazine, hydroxchloroquine, methotrexate. Humira and other TNF-a inhibitors do not!

Yes, but: Yes, but it is not a useful way to track the effectiveness of treatment of rheumatoid arthritis. To assess treatment of RA, the doctor does a tender joint count, a swollen joint count, listens to symptoms, and will occasionally do follow-up X-rays or laboratory work such as a sedimentation rate or C-reactive protein.