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A 39-year-old member asked:

can there be changes in rheumatoid factor?

3 doctor answers16 doctors weighed in
Dr. PHILIP WALLER
Rheumatology 33 years experience
YES: Rheumatoid factors can change sometimes day to day and also how the test is done. It also may change with the level of disease activity.
Dr. Thomas Namey
Rheumatology 48 years experience
Depends!: If a patient has RA, RF will go down with traditional DMARD Rx: sulphasalazine, hydroxchloroquine, methotrexate. Humira and other TNF-a inhibitors do not!
Dr. Pierre Moeser
Specializes in Rheumatology
Yes, but: Yes, but it is not a useful way to track the effectiveness of treatment of rheumatoid arthritis. To assess treatment of RA, the doctor does a tender joint count, a swollen joint count, listens to symptoms, and will occasionally do follow-up X-rays or laboratory work such as a sedimentation rate or C-reactive protein.

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A 45-year-old member asked:

Can there be large changes in rheumatoid factor over a few weeks?

1 doctor answer2 doctors weighed in
Dr. Thomas Namey
Rheumatology 48 years experience
Yes.: Particularly if taking dmards. These are drugs to treat ra. Rf levels are now reported in units rather than dilutions, so big drops do occur, and a a good sign that the medication is working.

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Last updated Oct 11, 2018

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