What does malignant neoplasm of liver mean? very bad news?

This means cancer: A malignant neoplasm of the liver means cancer. What it doesn't tell you is if it originates from the liver, or whether it started in another organ and spread to the liver. This makes a huge difference in how the liver tumor is treated. Generally cancer that has spread to other organs is a difficult situation, but there are some examples where we have excellent therapies for these cancers.