Can you get coronary artery disease from drugs?

Yes: "drugs" is a vague term but if you mean recreational drugs then yes. Marijuana is as bad if not worse than cigarettes. No filter, held for extended time in lungs, and often contains unknown contaminants.So if smoking is a known risk factor....Cocaine tends to cause intense coronary artery vasospasm.This can damage the endothelium and allow cholesterol to deposit in the vessels.