Can frostbite lead to an amputation?

Yes: If the tissue damage is extensive enough, this can lead to amputation.

YES!: If the frostbite is severe enough to cause extensive tissue damage, then absolutely, yes. It is mostly soft tissue that gets frozen first because of the high water content. When the water in the cells freezes, it usually expands to an extent that the cells rupture and die. High dergees of tissue death can easily lead to the need for certain levels of amputation to save the patient's life.