Who experiences major depression most?

Biopsychsocial Facto: Biological is inheritance, psychological is low self esteem, social is traumatic events or losses.

Major depression: Lifetime prevalence of major depressive disorder is approximately 16.5%. Females are 70% more likely than males to experience major depression. The average age of onset is 32 years old. There is a genetic contribution, the specific genes have not been identified. It is thought that life stressors interact with this vulnerability to result in major depressive episodes.