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A 29-year-old member asked:

Will pulmonary hypertension run in families?

3 doctor answers7 doctors weighed in
Dr. Mark Avdalovic
Pulmonary Critical Care 26 years experience
Potentially: Potentially but is is very rare. Likely less than 1 in a million. There is a mutation that is frequent among patient with unexplained pulmonary htn, formally termed idiopathic pulmonary arterial hypertension. Current research is focused on identifying potential target of therapy that involve the genes related to familial pulmonary htn.
Dr. Charles Burger
Internal Medicine - Pulmonary Critical Care 37 years experience
PAH may be inherited: Up to 5% of patients with pulmonary arterial hypertension (pah) may have a genetic or heritable cause. Research studies have identified a genetic abnormality affecting bone morphogenetic protein receptor 2 (bmpr2) that appears to predispose a patient to pah. Fortunately, even if an individual inherits the abnormal gene, the likelihood of developing pah is only 1 in 5.
Dr. Donald Elton
A Verified Doctoranswered
35 years experience
Sometimes: There are some inherited forms of pulmonary hypertension that are very rare but pulmonary hypertension can result from certain collagen vascular diseases like scleroderma and sometimes these run in families.

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Last updated Jul 7, 2020


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