A member asked:

Why do tricyclic antidepressants prevent migraines?

A doctor has provided 1 answer
Dr. Alan Koenigsberg answered

Specializes in Psychiatry

Serotonin modulation: An excellent question. Amitriptyline affects multiple neurotransmitters, and it is believed that its modulation of serotonin calms the nerves that stimulate migraines.

Answered 2/16/2015

3.2k views

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