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A member asked:
What binds to mast cells and causes them to degranulate?
A doctor has provided 1 answer
Amongst others, IgE: IgE is an antibody that binds to the mast cell surface (aka "allergy antibody"). Its binding to an allergen causes the mast cell to deganulate. Non-IgE molecules can also cause mast cells to degranulate or just lower the threshold level for degranulation. These include signalling molecules (cytokines/hormones), drugs such as narcotics and NSAIDS, neuropeptides, tissue injury and microbes/toxins
Answered 4/2/2015
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