A member asked:

Male.estradiol 66pg/ml after 2 months clomid (clomiphene) 25mg/day.estradiol was 24pg/ml before.what explains the increase?total t went from 199 to 337 ng/dl. why?

A doctor has provided 1 answer
Dr. Julie Abbott answered

Specializes in Preventive Medicine

Clomid (clomiphene): stimulates the pituitary gland in the brain to produce more sex hormones. In men, clomid (clomiphene) stimulates LH (luteinizing hormone) which prompts Leydig cells in the testes to produce more testosterone which can convert to estrogen, so it would not be unexpected to see a rise in both of those hormones. This improves fertility. Clomid (clomiphene) works similarly in women promoting ovulation and fertility as well.

Answered 12/30/2014

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