A member asked:

In the past month my ana has gone from neg to 1:320 to now 1:640 and my c4 is borderline low. severe joint pain nose sores why can't i get a diagnosis?

2 doctors weighed in across 2 answers

Diagnostic criteria: It takes more than ANA to make a diagnosis. You may visit this site for criteria for a diagnosis of SLE and there are similar criteria for other auto-immune disorders. http://www.lupusresearchinstitute.org/lupus-facts/lupus-diagnosis

Answered 12/9/2014

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May be autoimmune: Your indicated pregnancy; was that recent? A C4 can be elevated if PG somewhat so a "borderline low" C4 may be significant. Your increasing ANA test titer in concert with your joint pain and nasal symptoms suggest the possibility of a "connective tissue" disorder. Thyroid disorders can also be associated with a positive ANA but considser seeing a Rheumatogist to see if a diagnosis can be made.

Answered 12/23/2014

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