What is the safest intravenous administration of the drug epinephrine?

Close supervision: This is a strange question. IV epinephrine is typically only used in an ICU setting for people who are critically ill. It must be given under constant supervision, as too much will cause death. Epinephrine is also used for severe allergic reactions causing anaphylaxis. In this situation, it is given intramuscularly through an autoinjector (prefilled with the correct amount)