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A 42-year-old member asked:

what is the difference between type i hypersensitivity and type ii?

1 doctor answer5 doctors weighed in
Dr. Michael Zacharisen
Allergy and Immunology 33 years experience
Big difference: Type 1 is mediated by the IgE antibody and responsible for anaphylaxis, hay fever, allerg etc. Allergy skin test can identify these. Type 2 is mediated by IgG or IgM antibody and complement proteins that are "cytotoxic" that ends up killing the target cell. Examples of this are hemolytic anemia, Graves disease, Myasthenia gravis, Rheumatic heart disease, etc. For anemia, a Coombs test is used

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Similar questions

A 32-year-old member asked:

Is there a formal diagnosis for hypersensitivity to clothing?

1 doctor answer4 doctors weighed in
Dr. Brian Novick
Allergy and Immunology 43 years experience
Patch testing: Depending on the symptoms you develop, keep track of the types of clothing and see an allergist. They can often do a patch test to confirm your suspicions.
A 36-year-old member asked:

What could hypersensitivity to beer indicate?

1 doctor answer4 doctors weighed in
Dr. Steven Machtinger
Allergy and Immunology 44 years experience
Hops or barley: There are some people allergic to hops or barley used to make beer. Its may also be that the alcohol in beer causes nasal congestion that you mistake for allergic rhinitis. Try drinking a clear spirit like vodka or gin. If those cause the same symptoms as beer the cause is the drug effect of alcohol on your nose.
A 42-year-old member asked:

What antiretroviral medications can cause a life threatening hypersensitivity?

1 doctor answer2 doctors weighed in
Dr. Michael Zacharisen
Allergy and Immunology 33 years experience
Any drug : Any drug can cause a severe allergic reaction. Some medications are more likely than others such as sulfa, aspirin, penicillin, etc. During 20 years of practicing allergy, I have rarely seen a severe reaction to an antiretroviral medication although this is just my experience.
A 36-year-old member asked:

Possible hearing hypersensitivity. How do I get tested?

1 doctor answer3 doctors weighed in
Dr. Richard Wasserman
Allergy and Immunology 44 years experience
Audiologist: An audiologist can do a hearing test. If you are concerned about an ear problem, you should see an otologist.
A 44-year-old member asked:

Help please? What is the difference between type i hypersensitivity to type ii?

1 doctor answer5 doctors weighed in
Dr. Al Hegab
Dr. Al Hegabanswered
Allergy and Immunology 40 years experience
Type I is immediate: hypersensitivity reactions, involves IgE with histamine and other mediators release from mast cells, while type II is cytotoxic hypersensitivity reactions involving IgG or IgM bound to cell surface antigens, with subsequent complement (a protein in the blood) fixation, there are also type III and type IV reactions, type I reactions are responsible for immediate allergic symptoms to foods or drugs

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Last updated Dec 2, 2015
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