Depends: Gangrene is dead tissue. It can be painless, as in dry gangrene of a toe in a person with diabetes or vascular disease. Or it can be very painful, if it is somewhere that has intact nerve endings. Medical attention is mandatory, because if untreated, it can--and frequently does--lead to death. Even treatment sometimes is futile if it arrives too late.
Answered 5/26/2015
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