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A 36-year-old member asked:

What difference is there between glyburide and glimepiride medications?

2 doctor answers3 doctors weighed in
Dr. Thomas Knecht
A Verified Doctoranswered
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Same family: Hi. Glyburide is a second generation sulfonylurea and glimepiride is a 3rd generation. They work at the same receptors on the beta cell (the pancreatic cells that make insulin) and stimulate insulin release. Glimepiride is preferable because of less metabolite build up in kidney disease, but they're VERY similar. I never use them. In my opinion, based on good science, we have much better drugs.
Dr. Michael Kleerekoper
A Verified Doctoranswered
A US doctor answeredLearn more
Diabetes: Either glyburide or glimepiride can be prescribed for management of diabetes. There may be a cost difference in your favor or you doctor may have a good reason to prescribe one or the other. More important - you need to take control of your eating habits, your weight (if overweight), and your exercise. Also please remember to measure your blood sugar regularly. Your doctor will advise you on dose

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A 42-year-old member asked:

Please explain what are the differences between glyburide and glimepiride medications?

1 doctor answer3 doctors weighed in
Dr. Thomas Knecht
A Verified Doctoranswered
A US doctor answeredLearn more
Similar mechanisms: Hi. Glyburide & glimepiride (& glipizide & others in the sulfonylurea class, for that matter) all work by the same mechanism to stimulate endogenous insulin release. They differ in duration of action, metabolites, accumulation in kidney disease, etc. They're archaic drugs that I never use anymore. There are much better type 2 drugs out there. Their one benefit - they're cheap.

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Last updated Mar 12, 2019
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