A member asked:

What are the tests for neural tube defect?

5 doctors weighed in across 2 answers

Neural tube defects: The primary test is the maternal serum fetal protein. If that is abnormal, an ultrasound examination and perhaps an amniocentesis.

Answered 8/17/2012

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Dr. Nikolaos Zacharias answered

Specializes in Maternal-Fetal Medicine

Ultrasound, MSAFP.: Prenatal ultrasound should have >90% sensitivity for open neural tube defect detection around 20 weeks. Earlier (>16 weeks) risk stratification can occur with screening maternal blood for AFP - although that is not diagnostic and has to be followed by ultrasound for confirmation and/or differential diagnosis. Fetal MRI is used as part of evaluation for possible fetal surgery to treat spina bifida.

Answered 6/10/2014

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