YES: Breast tenderness can certainly be a side effect of the Depo-Provera injection.
Answered 9/29/2016
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Hormonal changes: Any major shifts in your hormones (such as going off Depo) can cause changes in the breast and vaginal / uterine tissues. You will get back to normal in 1-3 months after stopping Depo usually.
Answered 11/17/2015
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