I've been have skin problems lately and have been taking benadryl, (diphenhydramine) it's not helping, would it hurt if i tool 125-150 mg of it?

Do not: Do not take that much Benadryl (diphenhydramine). The max dose that you can take at one time is 50mg spread out over 4 to 6 hours. If 50mg of Benadryl (diphenhydramine) is not doing the trick, the additional doses will not help anymore. That is the max benefit you will get from that drug. You need a more potent medication to be prescribed from your physician. Follow up with your primary for evaluation.