Magnesium: All PPIs may lower magnesium with long-term use. In March of this year, the FDA issued a warning about PPIs, saying regular use for a year or longer may lead to low levels of magnesium — increasing the risk of leg spasms, arrhythmias (irregular heart beats that can cause heart attack or stroke), and seizures. Their warning said the problem could be reversed with magnesium supplements. But in 25% of cases it couldn’t reverse the deficiency, and PPIs had to be discontinued.
Answered 9/29/2016
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