A member asked:

How can calcitriol deficiency cause osteoporosis?

6 doctors weighed in across 2 answers
Dr. Jeffrey Miller answered

Specializes in Rheumatology

Calcitriol is VitD : Vitmin d makes calcium absorption possible from the GI tract. Lack of it causes uncalcified bone to grow which is very weak and causes osteomalacia, a metabolic bone disorder. In children the disorder is rickets; adults get weak bones. It is cured by taking vitamin d by mouth.

Answered 2/16/2015

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Dr. Thomas Namey answered

Specializes in Rheumatology

Take D3 unless......: Take d3 unless your have kidney disease, or take certain anticonvulsants, which will block the formation of Calcitriol (1-25, dyhydroxy d). There are metabolites of d3 that may be helpful, and contribute to the many benefits of d! but without calcitriol, osteoporosis will ensue!

Answered 6/24/2014

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