Maybe maybe not: mirtazapine aka Remeron increases norepinephrine and serotonin to drive off depression plus it can cause drowsiness/ appetite gain effects due to antihistamine effects. It's the norepinephrine effect that could cause coldness due constriction of small blood vessels at the periphery eg skin and hence the sensation of cold. But the very same way is how anxiety can do this too. Talk to your doc further eg if it's Remeron, it would be dependent on the dose level and any sensitivity to the medication u may have.
Answered 9/26/2014
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