Unknown interaction: There is no known interaction between varenicline and amitriptyline. However, if your headaches get worse, then discuss with your neurologist. Always keep a log of the timing, duration, frequency, severity, and characteristics of your headaches, and take the log whenever you see your neurologist. Good luck on your smoking cessation journey. http://www.nlm.nih.gov/medlineplus/headache.html
Answered 4/15/2016
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