Is there an interaction between beer and predisone?

No: No but both can upset stomach Should not take together.

Yes: they both make you fat. The beer gives you a beer belly and the prednisone raises your blood sugar making you fat

Its a risk: There maybe a chance for stomach ulcers and gastrointestinal bleeding when these two substances are taken together. Both prednisone and alcohol can cause gastrointestinal irritation which might eventually lead to bleeding. As such, doctors would advise avoiding alcohol while undergoing prednisone treatment. Source: Prednisone And Alcohol - Drugsdb.com http://www.drugsdb.com/rx/prednisone/predniso