Initially my derm prescribe tetracycline with prednisolone, acne flare up,now she prescibe minocycline and xepasone.i cannot take accutane.what next?

One idea: Have you been offered a trial or spironolactone? I also trust that while you are using the meds listed, you're using a topical such as benzoyl peroxide.

What next?: What do you mean exactly? Is the new regimen not working? Besides the medication, you could add fish oil 3 grams a day. Omega 3s are very important against acne. It wouldn't hurt and may help quite a bit.