A member asked:

Cross tapering from venlafaxine er 150mg to nortriptyline 10mg for vestibular migrianes under my dr's supervision. any advice on the cross taper?

2 doctors weighed in across 2 answers

Go slow: Tapering off of Venlafaxine can be a challenge due to withdrawal symptoms. Tapering down in a gradual fashion over weeks instead of days can help ease the transition.Generally the new medication will be started at a low dose and worked up at the same time resulting in a "cross taper." Work with you MD if you have symptoms during the transition.

Answered 2/6/2015

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Dr. Paul Grin answered

Specializes in Pain Management

Very cautiously: Exercise particular caution when switching from Venlafaxine to Nortriptyline because SSRI will inhibit the metabolism of TCAs.

Answered 2/6/2015

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