India
A 18-year-old male asked:
Can pernicious anemia or severe vitamin b12 deficiency cause chronic non-specific duodenitis??
3 doctor answers • 3 doctors weighed in
A Verified Doctoranswered
56 years experience
No: If pernicious anemia is treated with Vit B-12 injections the patient will be otherwise normal. If not he will have atrophic gastritis, hematological problems as well as neurological ones
Created for people with ongoing healthcare needs but benefits everyone.
3.8k viewsAnswered >2 years ago
A Verified Doctoranswered
Family Medicine 35 years experience
Which came first?: Pernicious anemia results from the reduced gastric production of intrinsic factor. It is often associated with other autoimmune diagnoses. More commonly duodenitis/gastritis from NSAID overuse of meds like apirin and ibuprofen/Advil and infection with H.pylori causes B12 deficiency.
http://emedicine.medscape.com/article/204930-overview#aw2aab6b2b3aa
Created for people with ongoing healthcare needs but benefits everyone.
3.8k viewsReviewed >2 years ago
Dr. Le Wanganswered
Internal Medicine 38 years experience
Not clear: No clear evidence for the causal-effect relationship between the two. PA is an autoimmue-mediated destruction of parietal cells in stomach, resuling in impairmnent of B12 absorption. Certainly it is possible that pernicious anemia may co-exist or exacerbate duodenitis via immune process or loss of balance in duodenal fluid, or anemia. But the causal-effect relationship is not well established.
Created for people with ongoing healthcare needs but benefits everyone.
3.8k viewsReviewed >2 years ago
Last updated Mar 6, 2020
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