Can the depo-provera shot lead to infertility ?

No: Although depoprovera often produces an absence of menstrual bleeding it does not lead to infertility. If your menstrual cycles were regular and presumeably ovulatory they will return after depoprovera is stopped. If the cycles were irregular, that too will return to that state after depoprovera is discontinued.

Delayed return of ov: Ovulation is resumed on average 10 months after the last depoprovera shot sometimes longer.