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A male asked:

is it ok to take three different antihistamines?

2 doctor answers3 doctors weighed in
Dr. Dan Fisher
Internal Medicine 27 years experience
Possibly OK.: It probably won't hurt you, but you gotta wonder if it is helping you. I can imagine combinations of a topical antihistamine, a good general non sedating oral antihistamine, and a traditional sedating antihistamine .
Dr. Dustin Colegrove
Internal Medicine 12 years experience
Not a good idea: Unless specifically instructed by an allergist. I have only seen people on more than one antihistamine for severe recurrent hives (urticaria). Taking too many antihistamines at once can cause issues with urinary retention and other problems.

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Similar questions

A 38-year-old member asked:

What is the difference between first and second-generation antihistamines?

3 doctor answers5 doctors weighed in
Dr. Stephen Kimura
Allergy and Immunology 35 years experience
Side effects: The second generation antihistamines were developed to try and decrease the side effects of the first generations. Many are "purified" first generation antihistamines so they have the active effects without the side effects of drowsiness, sedation, dry mouth etc. They also tend to have longer half lives, meaning they can be taken once or twice a day not every 4 hours.
A 39-year-old member asked:

Are there any prescription antihistamines?

2 doctor answers12 doctors weighed in
Dr. Alex Martinez
Specializes in Allergy
A few: Antihistamines have been around for many years & many that used to be prescription are now available over-the-counter. A few antihistamines are still prescription, including some first-generation (sedating) medicines like periactin or palgic as well as second-generation (less-sedating) medicines like xyzal (levocetirizine) and clarinex.
Dr. Maziar Rezvani
Allergy and Immunology 21 years experience
Hydroxyzine is still prescription as well
Nov 23, 2011
Dr. Paul Carter
A Verified Doctor commented
A US doctor answered Learn more
Many prescription medications have antihistamine properties. Talk to your personal physician about which medications are right for you.
Jan 1, 2012
A 37-year-old member asked:

Is there any side effects when you take antihistamines for a longer period than a month?

1 doctor answer1 doctor weighed in
Dr. Lee Perry
Dr. Lee Perry answered
Allergy and Immunology 17 years experience
Unlikely: Antihistamines are generally safe to take for prolonged periods of time, as long as you're taking the proper dose. These medicines are notorious for causing drowsiness, although some over the counter antihistamines are non-drowsy.
A 30-year-old member asked:

Do antihistamines actually improve allergic conditionsor just suppress symptoms?

1 doctor answer2 doctors weighed in
Dr. Jeffrey Rosch
Allergy and Immunology 49 years experience
Antihistamines block: Antihistamines block the receptor sites for histamine released from mast cells or basophils in allergic reactions. As such they suppress symptoms to a variable amount. The only present treatment that can actually alter the allergic condition (diathesis) is immunotherapy (allergy injections).
A 42-year-old member asked:

I wish to know what are the side effects of antihistamines?

1 doctor answer2 doctors weighed in
Dr. Michael Tomeo
Dermatology 38 years experience
Tiredness : Mostly they cause tiredness but if you have a prostate problem , be careful don't drink and take benedry and don't drive or operate heavy machinery !

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Last updated Aug 4, 2014
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