Generally how long does it take for nortriptyline to take effect. when should i notice a decrease in pain? i started 10 mg qhs on 7/10/14.

TCI: It might take several weeks before you can see the full effect. Good luck.

If it works,: Your dosage is too low at this point, but if you can stand the adverse effects, and they will appear, a dose of 150 mg or higher might work within 2-3 weeks at earliest. However, Lyrica (pregabalin) works far better and may be tolerated far better also, if you can get that dose up to high ranges. But what is the cause? Better if you approach therapy and treat underlying disorder.