What happens if a patient is on massive drips of fentanyl ativan (lorazepam) & propofol & still shows signs of agitation, hypetensive,?

Sounds like: A patient in the intensive care unit, needs more sedation and blood pressure treated separately.

Tolerance varies: Assume you are talking about a pt in ICU, who is receiving sedation to help tolerate being on a ventilator. Every pt is different--some need much more than others, depending on age, severity of disease, pain level, etc. Intensive care physicians are experts at managing sedation to optimize pt comfort and BP. Sometimes it can take time to reach an ideal balance of meds.