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A member asked:
Can you tell me in laymans term, how does the amino acid substitution that results in abnormal hemoglobin have a drastic effect on protein structure?
A doctor has provided 1 answer
I will try: A protein has a complex twisted and folded shape that is dependent on the interactions of amino acids that can be far from the amino acid change. Some amino acids are charged (positive or negative) and some are not. Charged amino acids can repel or attract.
Answered 8/7/2014
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