A 38-year-old member asked:
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what happens if heparin affects the formation of thrombin then why pt is not prolonged?

1 doctor answer
Dr. Steve Howe
28 years experience Thoracic Surgery
Two pathway measures: The PT can be with VERY HIGH doses of heparin but generally remember our coagulation system has two primary enzymatic pathways measured differently in the lab 1. Intrinsic system :measured by aPTT (activatted partial thromboplastin time) and prolonged by heparin and 2. Extrinsic system: measured by PT (prothrombin time) and prolonged by coumadin (warfarin).They then converge at the final common pathway.
Answered on Aug 3, 2014

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