Wellbutrin, (bupropion) allergy meds, sinus meds, and booze? bad combo?

Of course: If the wellbutrin (bupropion) (WB) is for depression, drinking is likely to maintain the depression & interfere with the benefits of wb. The risk of seizures is higher combining heavy drinking + wb. Mixing WB with decongestants can cause agitation or anxiety. General rule is not to mix multiple drugs whenever possible, including alcohol.