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A 41-year-old member asked:

What causes muscle weakness in polio?

2 doctor answers6 doctors weighed in
Dr. Jay Rosenfeld
A Verified Doctoranswered
A US doctor answeredLearn more
See below: The polio virus attacks the nerves in the spinal cord that supply the muscles. Called motor nerves. Polio does not affect the nerves that deal with sensation. When the nerves die due to the polio virus, the muscles tend to wither and that is what causes the weakness. Post polio syndrome can occur 30-40 years later with new symptoms of weakness and fatigue. It is not a reactivation of the virus.
Dr. Ricardo Madrid
Neurology 54 years experience
the polio virus attacks and kills motor neurons of the spinal cord and brainstem with resulting flaccid paralysis of the muscles innervated by those neurons via the motor nerves
May 7, 2014
Dr. William Singer
Pediatric Neurology 51 years experience
Affects spinal cord: Polio affects the motor nerve cells in the spinal cord. When these nerve cells die, that reduces the messages that can be sent to muscles.

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