A member asked:

Is doxycycline in any way related to spontaneous suicide, mood swings, or depression?

6 doctors weighed in across 2 answers
Dr. Heidi Fowler answered

Specializes in Psychiatry

No: The only reported psychiatric side effect of doxycline is Anxiety (2%). If you are having thoughts about killing yourself, get seen at the nearest emergency room now. Have a friend or relative drive you or call 911 for emergency services for transport. You can call the National suicide hotlines 24/7 at 1-800-suicide (1-800-784-2433) or 1-800-273 – talk (1-800-273-8255) for support.

Answered 6/24/2015

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Doxycycline not: but isotretinoin is ( which is also used for acne). Make sure that you address suicidal ideation with the MD because if that occurs the medication needs to be discontinued and the patient observed in a monitored setting

Answered 7/5/2014

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