Wife diagnosis lyme, after 4 yrs of horrible fatigue, bad constipation, body pain, new allergies, and only getting worse, on abx for 6mos, please help?

Lyme disease: If in fact your wife's symptoms are truly related to "chronic" Lyme disease there is absolutely no evidence that antibiotics will be in any way effective. have your wife see a knowledgeable rheumatologist and stop wasting money and risking health issues by taking antibiotics.

If not: Already done a full workup is indicated including other issues than Lyme speak With your internist or information disease doctor