Does isotretinoin interfere with birth control pills (drospirenone and ethinyl estradiol)? is another contraception method recommended while on it?

Use two methods: You should use two methods of birth control once taking Isotretinoin ( Accutane) such as pills OCP and condoms. Isotretinoin doesn't interfere with efficacy of birth control pills

No: No, Isotretinoin does not interfere with your birth contrl pills. In fact you should stay on the birth control pills while on Isotretinoin due to risk of birth defects. An alternative might be the patch if you are looking for a change.