Yes: The present Cpx vaccine was first developed in Japan & used there for years (~16) before it was licensed here for general use.Stringent safety requirements of the FDA were met early on but a favorable cost/benefit was not worked out until later.Before the vaccine, Cpx deaths ~50/yr and hospitalizations 10K/yr, now both are rare. A few patients get a mild rash with blisters after the shot.
Answered 6/10/2014
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