A member asked:

Is there such thing as antihistamine resistance? seems like it becomes less effective the more i take it.

2 doctors weighed in across 2 answers

Drug Resistance: Tachyphylaxis: Rapidly decreasing response to a drug or physiologically active agent after administration of a few doses. Try a different antihistamine and that should work for you.

Answered 6/2/2014

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Possibly: Occasionally this happens. Stopping the antihistamine for a few days, and then switching to a new one may help.

Answered 6/10/2014

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